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R-421A Refrigerant 25 lb
R-421A Refrigerant 25 lb
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R-421A Refrigerant 25 lb
Refrigerant R-421A is a non-ozone-depleting HFC blend engineered as a direct replacement for R-22 in existing systems. It delivers reliable performance while allowing a smooth transition away from ozone-depleting refrigerants.
One of the key advantages of R-421A is its broad lubricant compatibility. It can be used with mineral oil, alkylbenzene (AB), or polyolester (POE) oils, helping reduce retrofit complexity and minimizing system modifications.
- Residential and commercial air conditioning systems
- Medium-temperature refrigeration
- High-temperature refrigeration applications
- Commercial and industrial cooling systems
When you purchase from Refrigerants Depot, you receive brand new, 100% virgin refrigerants that meet or exceed ARI-700 purity standards. Every cylinder is quality-tested to ensure dependable performance and system safety.
Most orders ship within 1 business day for fast and reliable delivery.

What Our Customers Say
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★★★★★
“Great customer service and top-notch refrigerants! I was a bit hesitant at first, but the products exceeded my expectations. The R-407C worked perfectly for my needs. I’ll be placing another order soon!”
Emily R
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★★★★★
“Ordered R-22 and R-134a cylinders for a big project. Everything arrived on time, well-packaged, and exactly as described. Plus, the free shipping was a great bonus! Highly recommend for any professional in the HVAC field.”
Carlos D.
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★★★★★
“I’ve been using the R-410A refrigerant from this store for a few months now, and I’m really impressed with the quality. Reliable product, fast delivery, and the best price I’ve found online. Definitely my go-to supplier from now on!”
John M.